Bioprocessing - Dr. Veronique Chotteau, Sweden

The Cell Technology Group (CETEG), focuses on the research of cell technology and in particular on the engineering of mammalian and human cell cultivation bioprocess for the production of biologics. CETEG develops new tools for high performance bioprocesses defined by intensification and optimisation for high productivity, high yield and high product quality. The engineering is carried out on the reactor and process level, as well as on the level of the cell itself. The foundation of the research in CETEG is in the understanding of the effect of the process microenvironment on the physiology of the cell. The group activities include high cell density perfusion and mathematical modelling, among others.

Key Personnel in the Project:

Veronique Chotteau, PhD, Group Leader

Meeri Mäkinen, PhD

Microfluidics - Assoc. Prof. Aman Russom, Sweden

Clinical diagnostics is one of the fastest developing areas for microfluidic applications. Microfluidics has the potential to spur the development of protocols and affordable instruments for specific blood analyses with minimal perturbation of individual cell populations. The Clinical microfluidics Lab (Cm-Lab) is developing different microfluidic based point-of-care devices for blood diagnostics. Focus is on sample preparation and integration with nucleic acid analysis. We are currently working on cell sorting for (i)cancer, (ii)allergy and (iii)HIV diagnostics as well as bacteria isolation for blood stream infections; In addition, we are developing different platforms for low cost molecular diagnostics, such as “Lab-on-DVD” and “Lab-on-Foil” platforms. The Lab-on-DVD platform, the group has converted a Standard DVD drives to act as a laser scanning microscope for low-cost cellular and molecular diagnostics. Cm-Lab has a number of national and international collaboration projects, and we are currently involved in three EU projects (CanDo, RAPPID and Digital Sequencing).

Key Personnel in the Project:

Analytical chemistry - Prof. Åsa Emmer, Sweden

The research group is specialised in bioanalysis. This includes sample preparation, chromatography, capillary electrophoresis and mass spectrometry of a wide variety of bioactive substances. Emphasis is on miniaturised analysis systems.

Key Personnel in the Project:

Åsa Emmer, Professor

Saara Mikkonen, PhD

Automatic Control - Prof. Elling Jacobsen

Within process control we consider mathematical modelling and control of chemical and biochemical systems, focusing on understanding the fundamental dynamic behaviour of process systems and how this behaviour can be modified by physical and synthesised feedback mechanisms. Within systems biology we consider learning the structure of intracellular networks from response data and analysing the impact of network interactions on cellular functions and their robustness. 

Key Personnel in the Project: